ANTIMICROBIAL PROPERTY OF AQUEOUS AND ETHANOL LEAF EXTRACT OF CELOSIA ISERTII

¹ Emudainohwo J.O.T., ²Ewharieme, A. D.; ¹Ejebe, D.E., ²Ewhre, L., ¹Agam, J.I.

¹Department of Pharmacology and Therapeutics Delta State University, Abraka

²Department of Microbiology, Delta State University, Abraka, Delta State, Nigeria

Email:  j.o.t.emudainohwo@yahoo.com

ABSTRACT

Studies on the aqueous and ethanolic extracts of medicinal and traditional plants/herbs has become a major focus of recent biochemical researches; in order to propose better models for manufacturing of modern drugs and design of microbes inhibition. This present study investigated the antimicrobial property of the aqueous and ethanolic leaf extract of Celosia isertii against micro-organisms: E.coli, S. aureus, P. aeruginosa, B. subtilis, S. typhi and K. pneumonia, using antibiotics; Ampiclox and Erythromycin as control. The disc diffusion techniques was used to test the sensitivity of the micro-organism to the extracts of C.isertiiand the results obtained show mean zones of inhibition between (7 + 0.2mm) to (10 + 0.3mm) for coldwater (aqueous) and (10 + 0.5mm) to (13 + 0.8mm) for ethanol extract. Micro-organisms showed sensitivity in the order: E.coli;(10 + 0.3mm) and (12 + 0.8mm), S.aureus; (8 + 0.2mm) and (11 + 0.6mm) and P.aeruginosa; (10 + 0.4mm) and (13 + 0.8mm), B.subtilis; (10 + 0.1mm) and (11 + 0.7mm), S.typhi (8 + 0.2mm) and (10 + 0.6mm) and K.pneumoniae; (7 + 0.2mm) and (10 + 0.5mm) for aqueous and ethanolic extracts respectively. The minimum inhibition concentration (MIC) ranged from 0.2 to 0.5mg/mL for ethanol extract while aqueous extracts appeared less effective. This result thus suggest the potency of Celosia isertii as an antimicrobial agent especially its extraction with ethanol at 0.5mg/ml although, further studies are recommended for its phytochemical screening/analysis.

Keywords: Antimicrobial Property, Leaf Extracts, Celosia Isertii