EFFECTS OF THE AQUEOUS SEED EXTRACT OF HELIATHUS ANNUUS L ON SOME BIOCHEMICAL INDICES OF PROSTATE PATHOLOGIES IN ALLOXAN-INDUCED DIABETIC RATS
1Saleh, B.G, & 2 Carol C.D
1Department of Integrated Science, College of Education Gindiri, Plateau State, Nigeria
2 Department of Biochemistry University of Jos. Plateau State, Nigeria
Email: Carrll42@yahoo.com, bitrussaleh@gmail.com
ABSTRACT
The aim of this study was to investigate the effect of the aqueous seed extract of helianthus annuus on some indices of prostate pathologies and contribute as to the relationship between diabetes mellitus and prostate pathologies. Twenty (20) Adult male wista albino rats (Rattus norvegicus) ranging from 150 to 250g weight were used in the study. Experimental diabetes was induced by single interperitoneal injection of alloxan-monohydrate dissolved in normal saline solution at a dose of 150mg /kg body weight. The rats were randomly divided into experimental and control groups of five rats each. The experimental groups (C, D) were given 400mg/kg b.w single daily dose of the aqueous extract for fifteen (15) days. Diabetes mellitus was confirmed in the experimental rats by the significant increase (p<0.05) in serum glucose level. Treatment with the extract showed a significant time dependant decrease (p<0.05). There was a significant (p<0.05) decrease in the serum level of prostate specific antigen and testosterone in the diabetic rats. Treatment produced a significant (p<0.05) increase. For oestrogen the diabetic control group rats showed significant (p<0.05) increase compared to the normal control group rats. The diabetic treated group rats showed a significant (p<0.05) increase in serum oestradiol level when compared to the diabetic control group rats. The effect of treatment was not time dependent. In conclusion Helianthus annuus L (sunflower) seed extract may have a beneficial effect in reducing risk of prostate pathology among diabetics.