EPIDIDYMAL EFFECT ON WISTAR RATS TREATED WITH ETHANOLIC EXTRACT OF Sida acuta LEAVE

Kebe, E. Obeten

Department of Anatomy and Forensic Science,

Cross River University of Technology, Okuku, Nigeria

Email: fredobeten@yahoo.com

Abstract

Ethanolic leaf extract of Sida acuta on the epididymis of adult wistar rats was evaluated in this study. Twenty five rats weighing between 180 – 220 g were assigned to five groups (control, olive oil control, low dose, medium dose and high dose) with five animals each. Normal control fed only on rat chow, olive oil control group received 0.5ml of olive oil. The experimental groups, low dose, medium dose and high dose received 500mg/kgBW, 1000mg/kgBW 1500mg/kgBW of the extract orally for 60days respectively. The animals were sacrificed at end of sixty days using chloroform anesthesia. The epididymis were dissected, sectioned for hematoxylin and eosin (H&E). Histological observations of the epididymis, showed dose dependent distortion of the normal cytoarchitecture of the organs, as the high dose revealed prominent distortion. This study thus suggests that consumption of Sida acuta at high dose may cause adverse effect on reproductive parameters and organs. Keywords: Sida acuta, epididymis, wistar rat, Histology