In-Vivo Evaluation of the Effects of Physcia grisea Extract on Alanine Aminotransferase (ALT) and Alkaline Phosphostase (ALP) Secretions in Albino Rats
1Onuorah, Samuel I., 2*Eze, Emmanuel I. and 3Ugwu, Godwin C.
1 Department of Animal Science, University of Nigeria, Nsukka, Enugu State, Nigeria
2 Department of Crop Science, University of Nigeria, Nsukka, Enugu State, Nigeria
3 Department of Science Laboratory Technology, University of Nigeria, Nsukka, Enugu State, Nigeria
E-mail: emmaclems2003@yahoo.com
ABSTRACT
Blood samples from four (4) groups (A, B, C and D) of albino rats of four rats per group were analyzed for Alanine Aminotransferase (ALT) and Alkaline Phosphatase (ALP) secretions. The analysis was carried out in two phases; phase 1 and phase 2. In phase one, which was the zero analysis, the weights of the animals were taken and the blood samples were collected and analysed. From the analysis, it was observed that there were secretions of ALT and ALP in the albino rats before administration. In the second phase of the analysis, the groups A, B, and C were orally administered 500 mg/kg, 250 mg/kg and 125 mg/kg of P. grisea respectively while the control (group D) were administered tragacant solution which was the vehicle used. After three weeks of administration, the blood samples were collected for final analysis to check the effect of P. greasia on both ALT and ALP secretions. It was however observed that there was significant decrease (P>0.05) in ALT and ALP secretions except in group D that served as the control. This could therefore be deduced that P. grisea may have a hepato-protective ability if properly utilized.